Low blood selenium concentrations in schizophrenic patients on clozapine
نویسندگان
چکیده
منابع مشابه
Clozapine Induced Neutrophil Cytotoxicity in Schizophrenic Patients
The risk of potentially life threatening idiosyncratic reactions, limited the use of clozapine therapy, in the treatment refractory schizophrenia. The present study aims to investigate the neutrophil cytotoxicity in the clozapine treated schizophrenic patients, as it is still prescribed frequently for psychiatric patients in Pakistan. The assessment was focused on the hematological and absolute...
متن کاملCase studies of adjunctive agents in clozapine-resistant schizophrenic patients.
Approximately 40%-70% of neuroleptic-resistant schizophrenic patients are nonresponders even to clozapine. Several clozapine augmentation strategies have come into clinical practice, although often without evidence-based support. This study aims to critically review all the reported case studies regarding the efficacy and safety of adjunctive agents in clozapine-resistant schizophrenic or schiz...
متن کاملClozapine Combined with Paliperidone Observations in Schizophrenic Patients with Insufficient Responses to Clozapine Monotherapy
Treatment resistance to clozapine often leads to antipsychotic combinations. Well-designed trials evaluated the add-on of several atypical antipsychotics, but the augmentation with paliperidone, the active metabolite of risperidone, has never been evaluated. Treatment of four cases resulted in a decrease of the PANSS-positive subscale, the mean initial clozapine dose could be lowered, mean prol...
متن کاملDouble-blind comparison of olanzapine versus clozapine in schizophrenic patients clinically eligible for treatment with clozapine.
BACKGROUND The treatment of schizophrenic patients who fail to respond to adequate trials of neuroleptic drugs is a major challenge. Clozapine has been one treatment option; however, it is not universally effective and is limited in its use by safety concerns. With the introduction of newer agents, their performance relative to clozapine is of great clinical interest. METHODS The primary obje...
متن کاملRelation of blood counts during clozapine treatment to serum concentrations of clozapine and nor-clozapine.
OBJECTIVE To determine the relation between serum clozapine and nor-clozapine levels and blood cell counts during clozapine treatment. METHOD We undertook a prospective longitudinal study of 37 consecutive patients with a diagnosis of schizophrenia treated with clozapine. We obtained informed consent and then determined serum concentrations of clozapine and nor-clozapine weekly. Clozapine was...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2003
ISSN: 0306-5251
DOI: 10.1046/j.1365-2125.2003.01773.x